Lymphatic Regeneration Within Porous VEGF-C Hydrogels for Secondary Lymphedema

Abstract

Lymphedema is an abnormal swelling, in which lymph production exceeds drainage capabilities. This occurs as a result of lymphatic vessel destruction during the removal of lymph nodes or subsequent radiation therapy in breast cancer treatment. Management of lymphedema remains a clinical problem. In adult lymphangiogenesis, VEGF-C has been shown to be a specific mitogen for lymphatic endothelial cells (LEC) via the VEGF-3 receptor. Ang-2 has recently been shown to be required for proper lymphatic development via the Tie 2 receptor.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA420366

Entities

People

  • Mauricio A. Contreras

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Arteries
  • Biological Sciences
  • Blood
  • Breast Cancer
  • Cardiovascular Physiological Phenomena
  • Cells (Biology)
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Health Services
  • Lymph Nodes
  • Lymphatic System
  • Lymphatic Vessels
  • Neoplasms
  • Polymer Chemistry
  • Surgery
  • Tissue Engineering

Fields of Study

  • Medicine

Readers

  • Marine Ecological Systems Migration
  • Oncology (Cancer Research).
  • Trauma Surgery or Emergency Medicine.