Magnetic Resonance Studies of Photosensitizers and Their Effect in Tumors
Abstract
In this project, we use specifically fluorine labeled photosensitizers which will be of utility in the treatment of breast cancer via photodynamic therapy (PDT). The accumulation of the photosensitizer in the tumor and the muscle are evaluated using noninvasive 19F spectroscopic modality in mice bearing RIF tumor. By determining the relative disposition of the sensitizer, we can determine the best time to irradiate the tumor causing minimal damage to nearby healthy cells around the tumor. The absorption, distribution and elimination of the labeled sensitizer is achieved by 19F spectroscopy of tumor models after administering a single dose of the sensitizer. The tumor destruction is achieved by irradiating the tumor with an appropriate wavelength laser light. The process of tumor destruction and the accompanying changes in the high energy phosphates and diffusion process are monitored by 31P and 1H MR studies. The 31P MR studies performed before and after the use of 19F labeled PS(DoD2) does not show any appreciable changes in the spectra but tumor regression was observed after PDT studies under fractionated laser doses. The corresponding nonlabeled compound did not show 31P spectra changes or tumor regression following PDT.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA420378
Entities
People
- Subbaraya Ramaprasad
Organizations
- University of Nebraska Medical Center