Therapy of Breast Tumor Cells Overexpressing c-cerbB-2/neu
Abstract
Two of the major barriers against the successful therapy of breast cancer are mutation of the tumor suppressor p53 gene and overexpression of the c-erbB-2/neu (HER-2/neu) gene. These conclusions have been drawn from many studies reported over the last decade for each of these two genetic defects. However, the possibility of interactions between these two genes in the treatment outcome with therapeutic antitumor agents are limited, and have led to conclusions that are inconsistent. The end result is that treatment decisions are made in absence of any objective information to guide the design of the regimen. Of further concern is the absence of any therapeutic agents that could be used under such circumstances. The present research project was proposed to address these limitations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2003
- Accession Number
- ADA420773
Entities
People
- Zahid H. Siddik
Organizations
- The University of Texas MD Anderson Cancer Center