Mammaglobin and Lipophilin Related Molecules in Normal and Tumor Human Breast Tissue: Expression, Hormone Regulation and Functional Analysis
Abstract
Genes, expression of which is breast specific or is altered during breast tumorigenesis, represent potential targets for new preventive and curative strategies. Such genes, Mammaglobin (MGBl), hSBEM (Human Small Breast Epithelial Mucin), Psoriasin, Estrogen receptor beta (hERB) and SEA (Steroid receptor RNA activator), are currently studied in our group. We found that: MGBl expression correlates with ER (an established breast cancer prognostic and predictive factor), but is not modified by hormone treatments, suggesting it might be a new independent breast cancer prognostic marker. hSBEM, which represents an attractive candidate for a new breast tumor marker with obvious potential for cancer diagnostics can now be detected using specific antibodies. SEA, previously believed to believed to belong to the family of non-coding RNA and able to activate steroid receptor activity, is translated into a protein which function remains to be determined. Psoriansin, highly expressed in high risk DCIS, can contributes to breast tumor progression through modulation of Jabl activity. hERB isoforms have promoter-specific differential activities suggesting that they may have a role in differentially modulating estrogen action during breast tumor progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA420774
Entities
People
- Etienne R. Leygue
Organizations
- University of Manitoba