Consequences of Prolonged Hemorrhage on Oxygen Delivery to Skeletal Muscle Microcirculation
Abstract
The purpose of the proposal is to characterize global hemodynamics and microcirculatory oxygen transport in skeletal muscle in an animal model of severe (40 mm Hg), prolonged (4 hours) hemorrhagic hypotesion (HH) . The target pressure and length of hemorrhage were set in the Army's original request for proposals. Arterial and venous blood pressures, gases, acid-based status, glucose, lactate, electrolytes, hemoglobin, 02 delivery and consumption were measured before and up to 4 h after HH (mean arterial pressure, MAP = 40 mm Hg.) Ringer's lactate (RL) was used to maintain MAP. Fifty-three percent of rats survived greater than or equal to 3 h (survivors, S); others were considered non-survivors (NS) . Following HH, all rats required Rb infusion for greater than or equal to h. NS showed a significantly greater degree of metabolic acidosis that S. Respiratory rate, arterial PO2, O2Sat, O2 content, glucose and pH were significantly higher in S. Rate of Rb infusion, arterial K+ and PCO2 were lower in S. Arterial K+ and RR were the only parameters significantly different between S and NS at all time points during HH. The data suggest that early oxygenation and metabolic compensation are essential for survival of prolonged HH.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA420778
Entities
People
- Roland N. Pittman
Organizations
- Virginia Commonwealth University