Diagnosis of Breast Cancer Using Fluorescence and Reflectance Spectroscopy
Abstract
The goal of this grant is to characterize the fluorescence and diffuse reflectance properties of breast tissue, and identify features in the spectra which may be useful in diagnosing breast cancer. In the past 12 months in which the award was active, 3 reviewed manuscripts have been accepted for publication, and two conference presentations have been completed. Significant work includes characterization of the intrinsic fluorescence properties of normal and malignant human breast cell lines. It was found that the malignant cell lines have significantly different fluorescence properties for the fluorophores, tryptophan, and NAP(P)H. This suggests that these fluorophores could be important indicators of malignancy in tissue, and could be exploited in an in vivo diagnostic device. Additional work has focused on completion of a preliminary investigation to characterize fluorescence and diffuse reflectance properties in human breast tissue, and development of analysis techniques for interpreting spectral data.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA420812
Entities
People
- Gregory M Palmer
- Nimmi Ramanujam
Organizations
- University of Wisconsin–Madison