Pilot Study to Measure the Effects of NSAID Use on Angiogenesis and Apoptosis in Female Invasive Breast Cancer

Abstract

To examine the effects of NASIDs on invasive breast cancer we are performing a immunohistochemical analysis on 220 cases of breast cancer from Saskatchewan which has provided a complete drug history of each patient. We are assessing the tumors for COX 1 and COX 2, angiogenesis, estrogen receptor, proliferative index and the degree of apoptosis. Previous work has shown that some breast cancers over express cyclooxygenases COX 1 and 2 and a large epidemiological study conducted in Saskatchewan suggests that non-steroidal anti-inflammatory drugs may slow the growth of breast cancers and prevent metastases.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2003
Accession Number
ADA420843

Entities

People

  • E. Zorychta
  • John B. Richardson
  • M. C. Guiot
  • V. Tagalakis

Organizations

  • McGill University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Angiogenesis
  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Canada
  • Cell Physiological Processes
  • Classification
  • Continents
  • Electronic Mail
  • Geographic Regions
  • Information Operations
  • Neoplasms
  • North America
  • Pilot Studies
  • Security

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