Enhanced Peptide Radiotherapy of Prostate Cancer Using Targeted Adenoviral Vectors

Abstract

An adenovirus encoding the genes for human somatostatin receptor subtype 2 and bacterial cytosine deaminase (AdSTR2CD) was constructed. The SSTR2 allows for non-invasive imaging of gene transfer and therapy with radiolabled somatostatin analogues. The CD converts the prodrug 5-fluorocytosine (5-FC) to the toxic and radiosensitizing 5-fluorouracil (5-FU). Thus, it is hypothesized that AdSSTR2CD can be used for the simultaneous expression of SSTR2 and CD for the detection and treatment of prostate cancer. The purpose of this report is to state that there was no progress in the previous year due to the PI changing institutions.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA420846

Entities

People

  • Buck E. Rogers

Organizations

  • Washington University in St. Louis

Tags

DTIC Thesaurus Topics

  • Adenoviruses
  • Analogs
  • Biomedical Research
  • Bone Marrow
  • Counters
  • Diseases And Disorders
  • Gamma Counters
  • Gene Therapy
  • Hormones
  • Neoplasms
  • Pituitary And Hypothalamic Hormones And Analogues
  • Prostate
  • Prostate Cancer
  • Radiotherapy
  • Therapy
  • Tissues
  • Universities

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).