Multidisciplinary Strategies in the Prevention and Early Detection of Ovarian Cancer
Abstract
The general theme of this program deals with primary prevention and early diagnosis of ovarian cancer. The authors have identified several genetic changes in microscopic and early stage ovarian tumors in Project 1, suggesting that these changes may represent early events during ovarian tumor development and progression. They have shown that Protease M over-expressed in a majority of stage I tumors and can be secreted by ovarian cancer cells in Project 2, suggesting that it is a potential marker for early detection of the disease. Furthermore, the authors have demonstrated that estradiol significantly simulated normal ovarian epithelial cell proliferation in Project 3, suggesting that there may be relationships between therapeutic hormone usage and ovarian cancer risk. Finally, they have identified new classes of lysophospholipids elevated in serum and ascites in Project 4, suggesting that these lipids can not only be used as diagnostic but also as potential prognostic markers for disease progression and novel therapeutic targets. Several new techniques have been established and applied. Collaboration among investigators has been initiated and several manuscripts and abstracts have been generated. Also, experiments have been finished according to the Statement of Work originally proposed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA420870
Entities
People
- Samuel C. Mok
Organizations
- Brigham and Women's Hospital