Post Transcriptional Regulation of the Neurofibromatosis 2 Gene
Abstract
Neurofibromatosis type 2 (NF2) is associated with a homozygous inactivation of the neurofibromatosis 2 gene (NF2), which encodes a protein named merlin' for moesin-ezrin-radixin like protein (Trofatter et al., 1993). Despite Tntense study of the NF2 tumor- suppressor, the mechanism by which merlin acts to prevent tumor formation is not well understood (reviewed in Gusella et al., 1999; Gutmann, 2001). The NF2 transcripts undergo alternative splicing, generating a series of mRNA isoforms lacking one or more exons. Presently, the role of alternative splicing of NF2 mRNAs is not understood. NF2 isoform 1 (without exon 16) but not isoform 2 (containing all 17 exons) possess growth inhibitory properties (Gutmann et al., 1999).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA420890
Entities
People
- Long-Sheng Chang