Pathogenesis of Ovarian Serous Carcinoma as the Basis for Immunologic Directed Diagnosis and Treatment
Abstract
The etiology/pathogenesis of serous carcinoma, the most common type of ovarian cancer, is poorly understood. Until this is clarified the development of new diagnostic tests and therapy will remain empiric. The overall objective of our program is to identify biomarkers that define the molecular pathogenesis of serous carcinoma, and thereby develop an early detection test and antigen-specific immunotherapy for this deadly disease. During the first year of funding, significant progress has been made and the majority of specified tasks have been accomplished. This has led to five publications in high impact journals and the generation of important new research resources, including tissue and blood specimens, tissue microarrays, ovarian cancer cell lines, antibodies to novel ovarian cancer markers, and novel naked DNA vaccine constructs. In order to gain access to a wider variety of specimens including those that are not available in our tissue bank we have established a close collaboration with Dr Susanne Kruger Kjaer who is the principal investigator on the Danish population-based Malignant Ovary (MALOVA) study. This will improve the power of our studies. Continued support of this program will accelerate advances in diagnosis and treatment, leading an improved outcome for ovarian cancer patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA420911
Entities
People
- Robert J. Kurman
Organizations
- Johns Hopkins University