Ovarian Cancer Risk and Survival in BRCA 1/2 Carriers

Abstract

The goal of this project is to determine whether oral contraceptives (OCs) and parity are as protective against ovarian cancer in BRCA 1/2 carriers as they are for women in general (Specific Aim 1). The second goal is to determine whether there are survival differences between BRCA 1/2 1/2 carriers with ovarian cancer compared to women with sporadic disease (Specific Aim 2). The study employs a case-case design. We identified Jewish women with epithelial ovarian cancer. We genotyped these women for the 3 BRCA1/2 mutations found in Ashkenazi women. We compared oral contraceptive use and parity between carriers and non- carriers. We will also compare survival differences between the two groups.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2003
Accession Number
ADA420933

Entities

People

  • Francesmary Modugno

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Chemical Reactions
  • Diseases And Disorders
  • Dna Sequence Analysis
  • Drug Therapy
  • Epidemiology
  • Genetics
  • Health Services
  • Institutional Review Board
  • Ligation
  • Medical Personnel
  • Mutations
  • Neoplasms
  • Ovarian Cancer
  • Physicians
  • United States

Fields of Study

  • Medicine

Readers

  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.