Peripheral Benzodiazepine Receptor (PBR) in Human Breast Cancer

Abstract

The peripheral-type benzodiazepine receptor (PBR) is an 18 kDa high affinity cholesterol and drug binding protein, part of the aggressive human breast cancer cell phenotype in vitro. We report herein that in human biopsies elevated PBR expression is limited to certain cancers, such as those of breast, colon-rectum and prostate tissues, where elevated PBR expression is associated with tumor progression.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2003
Accession Number
ADA420939

Entities

People

  • Vassilios Papadopoulas

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Health Services
  • Medical Personnel
  • Oncology

Fields of Study

  • Biology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).