Phosphoinositide 3-Kinase/AKT1 Pathway and Human Ovarian Cancer

Abstract

During the last three years, we have demonstrated frequent activation (39%) of PI3K/AKT1 pathway in human primary ovarian cancer. The activation of this pathway is associated with late stage and high grade tumors, indicating that activation of PI3K/AKT1 plays a important role in ovarian tumor progression rather than initiation. Activation of - PI3K/AKT1 pathway induces malignant transformation and chemoresistance. Inhibition of this pathway by PI3K inhibitor or dominant negative AKT1 results in apoptosis and cell growth arrest as well as sensitizes ovarian cancer cells to cisplatin-induced cell death. We have also demonstrated that AKT targets ASK1/JNK/p38 pathway to promote cell survival. Further, we documented that farnesyltransferase inhibitor (FTI) and geranylgeranyltransferase I Inhibitors (GGTI) inhibit PI3K/AKT pathway to overcome chemoresistance in human ovarian cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2003
Accession Number
ADA420944

Entities

People

  • Jin Q. Cheng

Organizations

  • University of South Florida

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Health Services
  • Medical Personnel
  • Oncology
  • Proteins

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics
  • Oncology (Cancer Research).