Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implications in Fracture Repair and Wound Healing in Humans
Abstract
The primary goal of the project funded by the U.S. Army is to identify genes which play an anabolic role in bone tissue and soft tissue function, particularly during regeneration, and to clarify the function of these genes. To accomplish this goal, we have proposed 3 technical objectives during the funding period. These 3 Technical% Objectives are as follows: A. Technical Objective 1: Studies proposed in the first technical objective are designed to employ state-of-the-art molecular biotechniques to identify the gene located in mouse chromosome 1 that is involved in the regulation of peak bone density. B. Technical Objective 2: Our second technical objective has been focused on identifying the key genes that are involved in soft tissue repair/regeneration using inbred strains of mice as model systems. C. Technical Objective 3: The goal of our third technical objective is to identify and characterize novel genes, using ENU mutagenesis techniques and to elucidate the function of known genes that play a key role in the metabolism of bone and soft tissue.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA420947
Entities
People
- David J. Baylink