Characterization of the Hen as a Model for Human Ovarian Cancer
Abstract
Investigation of basic factors involved in malignant transformation of the ovary has been hampered by the lack of an appropriate animal model. Most animals, with the exception of the domestic hen, do not spontaneously develop ovarian cancer. The use of two related genetic strains, which differ in spontaneous incidence of ovarian cancer may reveal an important difference between the two strains that could underlie the differential susceptibility to ovarian cancer. We have examined many hens of both strains and have observed that the marked difference in incidence between the strains has been maintained. We have characterized the tumors in terms of ovalburnin expression as an indication of site or origin. We have also examined the expression of markers in the tumors. Our second approach was to manipulate the rate of follicle development and ovulation to examine the effect of repetitive ovulation on incidence. This experiment was not possible so we have instead focused on hormones related to ovulation. We found that the C strain has higher circulating levels of progesterone as compared to the K strain. Finally, we are studying regulation of the tumor by investigating receptor expression in the tumors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA420950
Entities
People
- Patricia A. Johnson
Organizations
- Cornell University