Screening for ATM Mutations in an African-American Population to Identify a Predictor of Breast Cancer Susceptibility
Abstract
The hypothesis being tested in this project is that a greater proportion of African-Americans with breast cancer harbor germline mutation in the ATM gene compared to African-American women without breast cancer. An additional objective is to determine the functional impact upon the protein encoded by the ATM gene for each mutation identified. Specific Aims: The specific aims of this project are to (1) screen 100 African-American breast cancer patients and 100 African-American women without breast cancer and (2) perform functional studies using cells from patients identified as ATM carriers to determine whether each ATM mutation identified affect radiosensitivity and levels of the protein encoded by the ATM gene for each mutation identified. The main accomplishment during the first year of this study was to establish and optimize all of the assays and technique that will be used in this project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA421128
Entities
People
- Barry S. Rosenstein
Organizations
- Icahn School of Medicine at Mount Sinai