Genetic and Molecular Characterization of Drosophila Brakeless: A Novel Modifier of Merlin Phenotypes
Abstract
During the 2nd year, we have continued the work on the circuit defined by genetic interactions, we have observed among scribbler, Merlin and Cyclin E. During this year, we have shown that: 1) the two scribbler isoforms (SbbA and SbbB) are not completely equivalent in their requirements for the regulation of proliferation; 2) scribbler regulates Cyclin E expression at the transcriptional level and 3) Merlin functions upstream of scribbler. In addition to this, we have identified a human homologue to scribbler (Hsbb) which remarkably shares a similar genomic organization to Drosophila scribble and we have also performed a genetic screen to identify genes involved in proper Merlin localization within epithelial cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA421198
Entities
People
- Dennis R LaJeunesse
Organizations
- University of North Carolina at Greensboro