Biological Difference Between Prostate Cancer Cells that Metastasize to Bone Versus Soft Tissue Sites
Abstract
The most common site for prostate cancer metastases to develop are the bone where they cause significant morbidity as well as contribute to the mortality of the patient. The molecular differences between metastatic prostate cancer and localized prostate cancer are not well established. Before prognostic markers and rational therapies can be developed to target this lethal form of prostate cancer, the molecular alterations associated with it need to be unmasked. We have hypothesized that we can identify genetic and biologic changes that are important in prostate cancer metastasis to bone and determine their functional significance in prostate cancer bone metastasis. In this last period, we have: Task 1: We have investigated the binding of VCap prostate cancer cells (derived from a bone metastasis) and DUCaP cells (derived from a soft tissue metastasis) to bone. Task 2: We have developed a model to investigate metastatic patterns of prostate cancer cells in a preclinical in vivo model. Task 3: We have identified genes differentially expressed between bone and soft tissue metastases of the same patient.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2003
- Accession Number
- ADA421201
Entities
People
- Kenneth J. Pienta
Organizations
- University of Michigan