AKT2 Oncogene and Phosphoinositide 3-Kinase in Human Breast Cancer
Abstract
We have previously shown frequent alterations of AKT2 and PI3K in human primary breast carcinomas. Recently, we have demonstrated that activation and overexpression of AKT2 contribute to chemoresistance by phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) and mammalian sterile 20-like kinase 1 (MST1) resulting in inhibition of apoptosis. We have also demonstrated that geranylgeranyltransferase I inhibitors (GGTIs) inhibit AKT and surviving pathways to overcome AKT- induced chemoresistance. In addition, no significant phenotype has been observed in MMTV-AKT2 transgenic mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA421343
Entities
People
- Jin Q. Cheng
Organizations
- University of South Florida