Breast Cancer Risk in Relation to Serum IGF-1, IGFBP-3, and Their Genetic Determinants: A Study Within the European Prospective into Cancer (EPIC)

Abstract

We are conducting a large case-control study nested within a prospective cohort, to estimate relative risks of breast cancer by serum levels of IGF-I and IGFBP-3, and to examine associations of polymorphisms in 15 candidate genes with levels of IGF-I, IGFBP-3, and cancer risk. Progress report: in the first two years of this project, 1084 breast cancer cases and 2116 control subjects were included in the study, and measurements of IGF-I and IGFBP-3 were (practically) completed. A first series of 23 SNPs were typed for all case and control subjects, and typing of 18 additional SNPs is ongoing. Major findings: Elevated serum IGF-I shows a moderate increase in breast cancer risk among postmenopausal women. Preliminary analyses also show significant associations of a number of SNPs and haplotypes with IGF-I, IGFBP-3, or breast cancer risk.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2003
Accession Number
ADA421424

Entities

People

  • Rudolf J. Kaaks

Organizations

  • International Agency for Research on Cancer

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Carrier Proteins
  • Data Analysis
  • Extraction
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetic Variation
  • Genetics
  • Genotypes
  • Growth Factors
  • Manufacturing
  • Measurement
  • Neoplasms
  • Population Genetics
  • Statistical Analysis

Readers

  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology