Development of KGF Antagonist as a Breast Cancer Therapeutic

Abstract

This grant proposal was to synthesize potential KGF antagonists which will then be evaluated for efficacy in vitro assay systems. The results generated for the propose study would be useful for designing new therapeutic agent for breast cancer. We were able to show some potential intracellular KGFR target small molecules whereas extracellular target synthetic peptide antagonist was not able to do during this period We also added a new dimension to an estrogen-KGF involved human breast microenvironment (i.e. KGF regulates estrogen receptor a mRNA and protein expression).

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA421458

Entities

People

  • Yasuro Sugimoto

Organizations

  • Ohio State University

Tags

DTIC Thesaurus Topics

  • Albumins
  • Amino Acids
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Culture Techniques
  • Epithelial Cells
  • Fibroblasts
  • Gene Expression
  • Health Services
  • Indicator Dyes
  • Molecular Dynamics
  • Molecules
  • Neoplasms
  • Proteins
  • Small Molecules

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).