Intervention Study of Flaxseed in Postmenopausal Women: Effects on Hormonal Biomarkers of Breast Cancer Risk
Abstract
The objective of this study is to determine if flaxseed supplementation to usual diet in postmenopausal women has a beneficial effect on important hormonal biomarkers of breast cancer risk. To date, a total of 47 eligible study participants have been successfully enrolled in the study from University of Massachusetts area; we anticipate that we will achieve the required sample size of 50 study subjects by 31 August 2003. Participants receive 6 weeks of usual diet plus 12 grams of raw flaxseed, followed by six weeks of usual diet plus 24 grams of raw flaxseed. Serum and urine are collected at baseline, 7 weeks and 13 weeks. At the completion of the study, serum and urinary levels of hormonal biomarkers of breast cancer risk will be measured (i.e., serum hormone levels: estradiol, testosterone, sex hormone binding globulin; urinary estrogen levels: 2/4-OHEl and 2/l6alpha-OHEl, genotoxic estrogen metabolites:total estrogens).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA421846
Entities
People
- Susan R. Sturgeon
Organizations
- University of Massachusetts Amherst