Role of Angiogenesis in the Etiology and Prevention of Ovarian Cancer. 2. Angiogenesis Factors in the Malignant Transformation of Ovarian Surface Epithelium

Abstract

Etiology of ovarian cancer is not completely understood Previous studies have shown that both genetic and epigenetic factors could contribute to ovarian tumorigenesis. Epidemiological studies suggest that number of ovulation and ovulation related gonadotropic hormones could play a role in the malignant transformation of surface epithelium. In this project, we will investigate how the normal ovarian epithelium acquires tumorigenic phenotype. Specifically, the effect of angiogenic growth factors in the etiology of ovarian cancer is studied using a model system.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2003
Accession Number
ADA421997

Entities

People

  • Sundaram Ramakrishnan

Organizations

  • University of Minnesota

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Angiogenesis
  • Biomedical Research
  • Cancer
  • Classification
  • Electronic Mail
  • Epithelium
  • Etiology
  • Information Operations
  • Maryland
  • Minnesota
  • Monitoring
  • Neoplasms
  • Ovarian Cancer
  • Security
  • Universities

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology