Genetic Definition and Phenotypic Determinants of Human Ovarian Carcinomas

Abstract

Ovarian cancer is the fourth leading cause of cancer-related death in U.S. women. This program project approaches the ovarian cancer problem by 1) establishing a human ovarian tissue and clinical data base core facility to support the proposed projects and future investigations, 2) identifying genes which are differentially expressed in ovarian cancers and thereby discovering biomarkers for early detection, 3) studying ovarian tumorigenesis in ovarian tissues obtained from germ line BRCA1 mutation carrier to better understand the interaction between mutational inactivation of BRCA1, the cellular caretaker gene and p53, the cellular gatekeeper gene, and 4) developing a genetically defined mouse model of epithelial ovarian cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2003
Accession Number
ADA422218

Entities

People

  • Beth Karlan

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Blood
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Databases
  • Detection
  • Epithelial Cells
  • Gene Therapy
  • Genetic Engineering
  • Genetic Structures
  • Genetically Modified Organisms
  • Genetics
  • Medical Personnel
  • Neoplasms
  • Ovarian Cancer
  • Peptide Growth Factors

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology