EphA2 Kinase Agonists as Novel Suppressors of Both Prostate Cancer Cell Motility and Growth: Structure-Function Relations and the Role of RAS/MPK Pathway

Abstract

There are three goals in this proposal. 1) To establish the expression profile of EphA2 during TRAMP prostate cancer development and progression, which will help determine the optimal window of EphA2 targeting. 2) To target EphA2 with its native and artificial agonists to see if they can suppress TRAMP prostate cancer development and/or progression. 3) To investigate the role of EphA2 during prostate cancer development by crossing EphA2- null mice with TRAMP mice. During the past 6 months since this modified grant was reactivated, we have made significant progress breeding and genotyping large number of animals required for achieving the goals.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2003
Accession Number
ADA422402

Entities

People

  • Bingcheng Wang

Organizations

  • Case Western Reserve University

Tags

DTIC Thesaurus Topics

  • Carcinoma
  • Cell Membrane Structures
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Growth Factors
  • Intercellular Junctions
  • Medical Personnel
  • Neoplasms
  • Peptides
  • Prostate
  • Prostate Cancer
  • Proteins

Readers

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  • Immunology
  • Molecular and genetic basis of cancer.