Role of Heregulin in the Neovascularization of Breast Carcinoma Cancer
Abstract
Several oncogenes, growth factors, hormones and hypoxia have been shown to up-regulate Vascular Endothelial Growth Factor (VEGF), an essential angiogenic factor for the progression of breast carcinomas. We previously demonstrated that he angiogenic factor CCN1 (CYR61), a member of the CCN family of growth regulators, is differentially expressed in breast cancer cells overexpressing Heregulin (HRG), a member of the epidermal growth factor-like growth factor family that regulates angiogenesis via up-regulation of VEGF expression and secretion. More recently, we found that CCN1- induced tumors in ovariectomized athymic nude mice did resemble human invasive carcinomas with increased vascularization and overexpression of VEGF.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA422418
Entities
People
- Javier A Menendez
- Ruth Lupu