Quantitative Characterization of Pulmonary Pressure-Volume Curve for Improved Care of Acute Lung Injury

Abstract

Continuous (sigmoidal (tangent-hyperbolic) and error-function) p-V model equations with four parameters are shown to represent clinical p-V curves accurately. The magnitudes of the four parameters, coupled with the normalized p-V equation, distinguish p-V data sets effectively. A mechanistic model of the total respiratory system is developed for the inflation process, relating characteristics of the p-V model equation to the internal respiratory conditions such as alveolar recruitment and elastic distension of tissues. The model is based on the principle of statistical mechanics applied to the total respiratory system as an ensemble of a large number of respiratory elements, each of which consists of a piston-spring subsystem. The ability of the mechanistic model to predict volume limits of the corresponding deflation process justifies its theoretical foundation.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2003
Accession Number
ADA422532

Entities

People

  • Uichiro Narusawa

Organizations

  • Northeastern University

Tags

Communities of Interest

  • Biomedical
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Acute Respiratory Distress Syndrome
  • Connective Tissue
  • Data Analysis
  • Data Sets
  • Distribution Functions
  • Elastic Properties
  • Energy Levels
  • Equations
  • High Pressure
  • Lung Diseases
  • Measurement
  • Normal Distribution
  • Operating Systems
  • Respiratory System
  • Static Pressure
  • Statistical Mechanics
  • Statistical Thermodynamics

Readers

  • Cardiovascular Physiology
  • Computational Modeling and Simulation