Increasing Oxygen Consumption During Shock
Abstract
Whole-body oxygen consumption is decreased after hemorrhage. Typical methods for increasing oxygen consumption have involved increasing the blood oxygen concentration using enriched oxygen gases, hemoglobins and fluorocarbon compounds; however, clinical trials involving these have not been totally successful. Increasing the oxygen concentration increases its diffusion rate through blood plasma; however, an alternative method would be to increase the diffusion coefficient of oxygen itself. This was shown to be possible using a naturally-occurring compound called crocetin. Crocetin also increased whole-body oxygen consumption in hemorrhaged rats and resulted in an increased survival rate. However, this occurred over a relatively small concentration range. Thus, trans sodium crocetinate (TSC) was developed, which also increases oxygen consumption in rats after hemorrhage and increases survival. TSC has also been shown to increase blood pressure and to reduce the acidosis that forms with hypoxia and to reduce damage to liver and kidney.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 04, 2004
- Accession Number
- ADA422762
Entities
People
- John L. Gainer
Organizations
- University of Virginia