A Population-Based Investigation of the Role of Focal Adhesion Kinase (FAK) and E-Cadherin Expression in Breast Cancer Promotion, Progression and Therapeutic Response
Abstract
Presented within this annual report are the details of the second year's progress and the preliminary results of the grant entitled "A population based investigation of the role of Focal Adhesion Kinase (FAK) and E-cadherin expression in breast cancer promotion, progression, and therapeutic response. In regards to the specific aims of the grant, immunohistochemical staining has been completed for both FAK and E-cadherin expression. Scoring has been completed on all 629 samples stained for FAK, providing information regarding the prevalence and pattern of FAK expression as well as its association with other known risk and prognostic factors for breast cancer. Scoring has been completed on all sample for E-cadherin following the development of a more-comprehensive scoring system. Collection of survival data is ongoing. Completing the proposed aims should elucidate the role of FAK and E-cadherin expression as a verifiable marker of disease aggressiveness, and will provide a better understanding of the biological behavior thus allowing for a more tailored treatment of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA422949
Entities
People
- Sandra L. Deming
Organizations
- University of North Carolina at Chapel Hill