Phase I Induction and Estrogen Metabolism in Women with and Without Breast Cancer and in Response to a Dietary Intervention
Abstract
The combined case-comparison study and randomized controlled trial (RCT) of 90 women is based on our prior edpidemiologic work (1-6) indicating that vegetables in the Brassica genus (e.g., broccoli, cauliflower, brussel sprouts) can modify estrogen metabolism by causing l7beta- estradiol (E2) to be metabolized to 2-hydroxyestrone (2HE) rather than 16alpha-hydroxyestrone (l6HE) thus producing a cascade of effects protective against breast cancer (2). Our plan is to enroll 45 postmenopausal women with breast cancer and 45 age-matched disease-free women and to compare them on: 1) AhR activation and its various protein products relevant to cancer including CYPlBl, PAZ- 2, and IL-l; and 2) levels of relevant estrogens-, E2, 2HE, and l6HE. The RCT will examine the effect of an intensive Brassica-rich diet intervention on AhR activation, its protein products, and estrogen metabolites in these women. This study is completing its third year of (no-cost) activity. All protocols for the collection of data are finalized and we have recruited 83 participants. The baseline data have been collected for case-comparison study and the last intervention cycle for the RCT will be in September 2003.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA422972
Entities
People
- James R Hébert
Organizations
- University of South Carolina