Enhanced T Cell Attack of Brain Micro-Metastases
Abstract
Brain-metastasizing breast cancer is a major clinical problem. Cell-mediated immuno- therapy is well-suited to attack it, but the efficacy must be increased. Our work addresses two basic research problems: A) The need for appropriate small animal models for blood-borne brain metastases, and B) the need for greater basic understanding of immune modulation in the brain. In year 1, we reported initial characterization of a novel rat model. In year 2, we reported identification, analysis, and solutions for a series of technical problems. Now, in year 3, we report : A) Further work in the tumor model, including: 1) Methods for quantitative analysis and depiction of micro-tumor distribution, 2) the distribution of blood-borne micro-metastases in untreated control rats, 3) provocative evidence that a simple needle wound can change the distribution; S) Further work on our proposed immunotherapy (injection of gamma interferon (IFN-g), including: 1,) New basic findings on immune modulation and delivery routes, 2) our approach to further probing the functional consequences of attempted immunotherapy; C) Related efforts, including a comprehensive special issue of the Journal of Neuro-Oncology on Brain Tumor Immunotherapy, co-edited and with an introductory overview by the PI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA422973
Entities
People
- Lois A. Lampson
Organizations
- Brigham and Women's Hospital