The Regulation of the Angiogenic Factor FGF Binding Protein (FGF-BP) by the APC/Beta-Catenin Signaling Pathway in the Progression of Breast Cancer
Abstract
Fibroblast growth factor binding protein (FGF-Bp) releases immobilized FGF's form the extracellular matrix and can function as an angiogenic switch molecule in cancer. We have determined that FGF-BP is upregulated in a portion of breast cancer and this upregulation is correlated with increased expression of beta-catenin. In this grant, we hypothesized that beta-cantenin can initiate angiogenesis in mammary carcinoma through FGF-BP. The aims were 1) to study the expression of FGF-BP in mammary tumorigenesis% progression of the APC/+ mouse and 2) to determine the mechanism of regulation of FGF-BP by the APC/beta- catenin signaling pathway in breast cancer. To date, we have shown a positive correlation of upregulation% of beta-catenin expression and FGF-Bp in breast and other tumors in the APC/+ mice. We have also shown that beta-catenin can directly induce FGF-BP gene expression through a transcriptional mechanism and that a.TCF site in the FGF-BP promoter is responsible for a major portion of this effect.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2003
- Accession Number
- ADA423021
Entities
People
- Anna T. Riegel
- Dora Stylianou
Organizations
- Georgetown University