BRCA2 Mediated Ubiquitination: Identification of Targets for Destruction
Abstract
Breast cancer can be a genetic disease passed from mother to daughter. BRCA1 is the gene that when mutated is responsible for half of inherited breast cancer cases and about 80% of the combined breast and ovarian cancer kindreds. Therefore, the function of the protein product of BRCA1, which is still unknown, must be extremely important in mammary and ovarian cells because when it is no longer there the cells become cancerous. This project aims to determine how the BRCA1 protein performs its protective function. We have set up a biochemical analysis of BRCA1, which should reveal key pathways regulated by BRCA1. Specifically, this project assays how BRCA1 directs the ubiquitination of cellular proteins, which influence the growth of the cell. In cells in which BRCA1 is mutated, perhaps the loss of the ubiquitination results in cancerous transformation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA423024
Entities
People
- Jeffrey D. Parvin
- Lea M Starita
Organizations
- Brigham and Women's Hospital