Assessing Vascular Oxygen Dynamics for Breast Tumor Prognosis: Comparison Between MR BOLD and Near Infrared Method
Abstract
The goal of this research is to investigate breast tumor vascular oxygenation, HbO2, and total hemoglobin concentration, Hbtotal, with respect to different interventions by correlating the results of Near Infrared Spectroscopy (NIRS) with BOLD in MRI. Up to now, I have demonstrated the capability and accuracy of NIRS as a non-invasive real time monitoring tool for tumor vascular oxygenation and blood volume by comparing the simultaneous measurements among three oxygen-related indicators and using 19F MRS of PFOB for blood volume measurement, respectively. Hyperoxic gases and hydralazine interventions have been intensively investigated by NIRS. Results showed that carbogen and oxygen breathing significantly elevate breast tumor oxygenation without difference in terms of magnitude, but with sluggish response in carbogen breathing. CO2 contributes a small portion to the elevation of DeltaHbO2. Only -40% of the breast tumors have good response in DeltaHbtotal with respect to Hyperoxic intervention. Administration of hydralazine effectively reduced both DeltaHbO2 and DeltaHbtotal in all the breast tumors. Meanwhile, I performed simultaneous measurements of tumor vascular oxygenation by NIRS and BOLD MRI, respectively. Results indicated the consistency of tumor global oxygenation obtained form the two simultaneous, independent measurements, with heterogeneous response displayed inside breast tumors in BOLD MR images, which may help us better understand, and further, interpret the mechanism of BOLD MRI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA423064
Entities
People
- Yueqing Gu
Organizations
- University of Texas at Arlington