Enabling Technologies for Advanced Soft Tissue Modeling
Abstract
Soft tissue properties represent a major and significant unknown in the domain of medical modeling and simulation. This program presents a 4-year research effort in defining tissue characteristics of three distinct organs (liver, spleen, and kidney) in vivo. Over the course of this program, we will use novel methods of tissue interrogation to characterize non-linear behavior during slow deformations, as would commonly be seen during surgical manipulations. We will then develop mathematical models that can be optimized to permit near real-time representations of organ behaviors, including the boundary characteristics of organs in situ. In year two we developed an in vitro experimental setup to approximate in vivo conditions; revised year one's testing instruments; devised a new large external indentation device for creep measurements; tested perfused porcine livers using these instruments; investigated a non-invasive technology for determining vessel characteristics; and began incorporating our results into finite element models. Collaborative efforts have allowed us to explore 30 real-time ultrasound as a means of investigating tissue mechanics; compare noninvasive forms of tissue property measurements (harmonic elastography) with our measurements; design a vocal fold tissue property measuring device; and develop a new optical testing modality that can later be used for whole organ validation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA423209
Entities
People
- Amy Kerdok
- Anna M. Galea
- Mark P. Ottensmeyer
- Robert Howe
- Steven L. Dawson
Organizations
- Massachusetts General Hospital