Molecular Characterization of Resistance

Abstract

This is an annual report of an IDEA Award to study the molecular mechanisms driving acquired antiestrogen resistance. We have identified several genes associated with resistance to ICI 182,780 (Fulvestrant. Faslodex). Our initial studies with NFkB have now been published (Mol Cell Biol, 23: 6887-6900, 2003). Further functional studies on the role of other genes are in progress, and we have made good progress with IRF-1 using a dominant negative construct. We also have built and tested neural network predictors to separate several antiestrogen resistance phenotypes. We have completed and published a method that allows us to visualize very high dimensional data while maximizing the discriminant information in the molecular profiles (J Signal Process Systems, in press, 2003). Thus, we have made substantial progress in defining initial components of a broader antiestrogen signaling network that is directly associated with acquired antiestrogen resistance.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA423243

Entities

People

  • Robert Clarke

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Breast Cancer
  • Cell Physiological Processes
  • Chemistry
  • Computational Science
  • Data Mining
  • Dimensionality Reduction
  • Genetics
  • Health Services
  • Information Science
  • Medical Personnel
  • Oncology
  • Proteins
  • Two Dimensional

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Systems Analysis and Design

Technology Areas

  • AI & ML