Paracrine Regulation of Prostatic Carcinogenesis

Abstract

This report summarizes the second year of activity on this study. The long term goal of this project is to better understand why some prostate tumors grow aggressively while others are extremely slow growing lesions. The objective of the proposed research is to establish immortalized stromal cell lines derived from normal human prostate and from human prostate cancer and to use these cells to investigate the role of IGFs in prostate cancer growth. In this year we have focussed on using the molecular tools made in year one to generate new immortalized stromal cell lines and to examine the effects of IGF signaling on malignant and pre-malignant epithelial cells. Data have been generated, which at this time must be considered preliminary, which suggest a role for IGF signaling in malignant progression as hypothesized in the original application. No major technical obstacles have cropped up. The project is close to its timeline predicted in the accepted statement of work.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2004
Accession Number
ADA423319

Entities

People

  • Simon W. Hayward

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Line
  • Cell Membrane
  • Cells
  • Culture Techniques
  • Epithelial Cells
  • Gene Expression
  • Infection
  • Mrna
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Regulations
  • Stromal Cells
  • Tissues
  • Wound Infections

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).