Molecular Markers of Estrogen Metabolism and Progression From High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) to Prostate Cancer
Abstract
The purpose of this case-control study is to investigate the association between genetic and encocrine markers of estrogen metabolism and prostate cancer progression. Androgens (e.g., testerone) may be critical in prostate cancercinogenesis, but there is accumulating evidence that estrogens facilitate progress during the later stages of prostate cancer formation (1-4). To explore the role of estrogens in human prostate carcinogenesis, we proposed to investigate the association between genetic and endocrine markers of estrogen metabolism and the detection of high-grade prostatic intraepithelial neoplasia (HGPIN) and stage I/II/III prostate cancer. While the first project year included protocol development and IRB approval, the second year of this study focused on subject recruitment and data collection. Specific accomplishments include recruitment of 146 subjects to the protocol (85% of eligible), with complete data collected form 129 subjects. We have expanded the recruitment base to the Veterans Hospitals, refined data collection materials, and are pilot testing our laboratory procedures. We anticipate successful project completion, and further details provided below are in parallel with the statement of work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2004
- Accession Number
- ADA423460
Entities
People
- Jay H. Fowke
Organizations
- Vanderbilt University Medical Center