The Role of IQGAP1 in Neoplastic Growth and Metastasis
Abstract
The purpose of this proposal is to evaluate the role of IQGAPl in neoplastic transformation and metastasis of breast epithelial cells. The main emphasis is on whether IQGAP is involved in invasion and metastasis of transformed breast epithelial cells, as well as the possible involvement of IQGAPl in regulating b-catenin function. Major findings to date are: (i) there is a high level of expression of IQGAPl in breast epithelium; and (ii) overexpression of IQGAP1 in mammalian cells enhances cell migration and proliferation. These data reveal that IQGAPl has a fundamental role in cell motility and invasion in breast epithelium. This information could have potential therapeutic implications in patients with breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA423466
Entities
People
- David Sacks
- Monideepa Roy
Organizations
- Brigham and Women's Hospital