Dietary Genistein and Prostate Cancer Chemoprevention
Abstract
The disease of cancer is usually attacked at time of diagnosis, and even chemoprevention is not usually considered until adulthood. Our hypothesis is that windows of development hold the key for chemoprevention of prostate cancer. We have previously demonstrated that genistein is bioavailable to the rat prostate and that life-time exposure to physiological concentrations of genistein suppressed the development of chemically-induced prostate cancer. The purpose of our research is to determine if there is a developmental window for this chemoprevention and the mechanism(s) of chemoprevention. We have demonstrated that neonatal and prepubertal exposure to genistein via the diet does not alter development of the prostate buds in 21 and 35 day old rats. More recently, we have demonstrated that prepubertal, as well as adult and lifetime, exposure to genistein in the diet down regulated androgen receptor, but not estrogen receptors alpha and beta, expression in the dorsolateral prostate of rats. Down regulated androgen receptor is consistent with genistein suppressing prostate cancer development. Short term exposure to genistein having a permanent effect on androgen receptor expression is hypothesized to occur via androgen receptor promoter DNA methylation. Tumorigenesis studies are completed and are in the process of being evaluated for histopathology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2004
- Accession Number
- ADA423480
Entities
People
- Coral A. Lamartiniere
Organizations
- University of Alabama