Toward Optically Monitored Cytosensors

Abstract

Fish scales display arrays of thousands of colored living cells known as chromatophores. In this study, the use of color changes in isolated lish scales was evaluated as a rapid warning signal for delayed neurotoxic agents. The focus was on detecting delayed effects of organophosphate nerve agents like sarin, though the less toxic diisopropylfluorophosphate (DFP) was used as a sirnulant. DFP caused rapid and long-lasting scale color changes. These signals were readily visible and quantifiable, especially for the brightly iridescent scale colors. DFP induced color changes in scales at similar dose-sensitivity and about 300 times more rapidly than in standard animal models. Scales thus showed promise as toxicity monitors.

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Document Details

Document Type
Technical Report
Publication Date
May 17, 2004
Accession Number
ADA423598

Entities

People

  • Philip N. Mcfadden

Organizations

  • Oregon State University

Tags

Communities of Interest

  • Sensors

DTIC Thesaurus Topics

  • Animals
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Epithelial Cells
  • Fish
  • Nerve Agents
  • Neurons
  • Organophosphates
  • Sensitivity
  • Toxicity
  • Warning Systems

Readers

  • Human-Computer Interaction (HCI).
  • Nanocomposite Materials Science
  • Neurotoxicology