Targeting Human Breast Cancer Cells that Overexpress HER-2/neu mRNA by an Antisense Iron Responsive Element

Abstract

In this project, we attempt to establish the utility of an antisense iron-responsive element (AS-IRE) -mediated gene expression system to targeting HER-2/neu-overexpressing breast cancer cells. During the funding period, we have finished the proposed goal stated in Task 1 by identifying the optimal" HER-2/neu antisense IRE, i.e., AS-IRE4. Moreover, we showed preferential cell killing in HER-2/neu-overexpressing MDA-MB-453 cells using hTERT-AS-IRE4-Bax as opposed to in low HER-2/neu-expressing MDA-MB-468 cells (Task 2).

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2003
Accession Number
ADA423682

Entities

People

  • Duen-hwa Yan

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antineoplastic Agents
  • Blood
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Chemistry
  • Gene Expression
  • Gene Therapy
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Ovarian Cancer
  • Prostate Cancer
  • Proteins
  • Therapy

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Operations Research