Novel Functional Screen for New Breast Cancer Genes
Abstract
All cells are subject to continual DNA damage. For this reason, elaborate pathways have been developed to monitor DNA damage and to coordinate cell cycle progression with DNA repair. To date, over 70 genes involved in DNA damage surveillance and repair have been identified (Wood, Mitchell et al. 2001). These genes include those involved in mismatch repair, homologous recombination, non-homologous end joining, and signaling cascades that respond to DNA damage. However, only a few of these genes have been shown to be associated with breast tumor development. The very large number of genetic alterations in breast tumors, and genetic heterogeneity even within a single breast tumor, strongly suggest that other repair genes must play a role in breast tumorigenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA423726
Entities
People
- Mary-claire King
Organizations
- Seattle University