Role of Casein Kinase 1 and DARPP-32 in Parkinson's Disease
Abstract
Parkinson's disease affects 1% of the population above the age of 65. The major neurological impairments are intimately related to the progressive degeneration of dopaminergic neurons. In order to develop improved treatments for Parkinson's disease, it is crucial to increase our fundamental understanding of dopaminergic neurotransmission. By using mice with targeted deletion of the gene encoding DARPP-32, we have demonstrated that DARPP-32 plays a key role in the actions of dopamine. The present proposal is devoted to studies of the effects of dopamine and other neurotransmitters acting via DARPP-32 in CK- 1 mutant mice and animal models of Parkinson's disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA423742
Entities
People
- Paul Greengard