The Role of Maspin in Prostate Tumorigenesis and Development
Abstract
The object of this proposal is to understand the tumor suppressor function of maspin in prostate, and to explore maspin's role in normal prostate development. Maspin knockout mouse model will be employed to study the effects of loss of maspin function on mouse prostate tumorigenesis and development. We hypothesize that the presence of maspin (by stable transfection or by adenovims mediated maspin gene delivery) will prevent or delay prostatic tumorigenesis and metastasis, while loss of maspin in mouse model will render it more susceptible to tumor formation and metastasis. We will take advantage of the powerful tool of mouse genetics by crossing maspin knockout mice with a well characterized mouse prostate cancer model (TRAMP) to test this hypothesis. Prostatic tumorigenesis and normal prostate development will be studied using a variety of established techniques, including organ culture, histopathology, and molecular biology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2004
- Accession Number
- ADA423802
Entities
People
- Ming Zhang
Organizations
- Baylor College of Medicine