99HRT Prenatal Alcohol Exposure Damages Brain Signal Transduction Systems
Abstract
This report details our progress during the third year of a three-year proposal. The proposal's overall goal is to uncover biochemical mechanisms that underlie learning and memory. These studies have yielded novel information about the effects of fear conditioning on brain phospholipase C-Betala (PLC-Betala), indicating that PLC-bla may play an important role in the biochemical processes underlying fear-conditioned learning and memory formation. We have uncovered the molecular basis of the observed association between PLC isozymes and extracellular signal-regulated protein kinase. In addition to increasing our understanding of the biochemical basis of learning and memory, these studies have yielded important information about the neurochemical mechanisms that underlie fear and stress, and, consequently, may provide insight into the neurochemical basis of posttraumatic stress syndrome.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA423814
Entities
People
- Kevin K. Caldwell
Organizations
- University of New Mexico