Regulation of Prostate Tumor Cell Line Proliferation and Tumorigenicity by ErbB4

Abstract

ErbB4 is a member of the ErbB family of receptor tyronsine kinases, a family that also includes the Epidermal Growth Factor Receptor (EGFR.ErbBl), ErbB2/HER2/Neu, and ErbB3/HER3. In small pilot studies, ErbB4 expression was detected in normal prostate epithelium but was absent in prostate tumor samples. Thus, we have hypothesized that ErbB4 is a potential prostate tumor suppressor. We have tested this hypothesis using constitutively-active ErbB4 mutants. The constitutively-active Q646C ErbB4 mutant inhibits drug-resistant colony formation by human PC-3 and DU-l45 prostate tumor cell lines. Analyses of additional ErbB4 mutants indicate that growth inhibition by the Q646C ErbB4 mutant appears to require phosphorylation of ErbB4 Tyr984 and Tyr1O56 as well as ErbB4 tyronsine kinase activity.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2004
Accession Number
ADA424025

Entities

People

  • David J. Riese

Organizations

  • Purdue University

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Biomedical Research
  • Biotechnology
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Media
  • Fibroblasts
  • Health Services
  • Infection
  • Proteins
  • Tissues
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).