Role of Melatonin in the Prevention of Breast Cancer in Patients With Cystic Breast Disease
Abstract
The primary objectives of this study are to establish a clinical breast cyst fluid (BCF) sample bank among patients with gross cystic breast disease (GCBD) in order to study the relationship between GCBD, melatonin and related growth agents in BCF, and breast cancer risk. BCF samples form participating patients will be used to elucidate the contribution of melatonin and related growth agents (EGF, TGF-beta, DHEA-S) to the oncostatic effects of BCF on MCF-7 human breast cancer cells. This project is currently in its final year, which was added as a no-cost extension to the original study. Progress through year 3 included continued patient enrollment and completion of biochemical as says and growth experiments for incoming BCF samples. Patient recruitment is scheduled for completion in the near future and statistical data analyses will proceed in this final grant year. Preliminary results obtained form interim statistical analyses are consistent with previously reported findings. In summary, cell culture growth experiments using BCF samples and corresponding biochemical composition assays continued in year 3. This project is scheduled for completion in the upcoming grant year.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA424033
Entities
People
- Robert L. Wells
Organizations
- Colorado State University