Breast Cancer Susceptibility and DNA Damage/Repair
Abstract
The specific hypothesis was that women who have selected polymorphic variants in genes that predispose them to poorer repair of DNA damage will have greater breast cancer risk. Polymorphisms in base excision repair (xRCCl), nucleotide excision repair (XPD, XPC), double-strand break repair (XRCC3, Rad5l, LIG4) and checkpoint-control (CDKN2A) genes were investigated. A secondary hypothesis was that risk may be further accentuated by lifestyle-related exposures to carcinogens or oxidants. A nested case control study of 612 matched pairs was conducted within the NYU Women's Health Study, a prospective study of over 14,000 healthy women aged 35-65 who were enrolled in the study during 1985-91. Genotyping was performed using RFLP. Statistical analyses were controlled for ethnicity, age, and various risk factors for breast cancer. There was a statistically significant increase in breast cancer risk for women who had the homozygous variant genotype for the XPC-PAT+ polymorphism (OR=l.41, 95% CI: 1.04-1.91). Further analyses suggested that women with the variant allele had an 80% greater (p=O.09) breast cancer risk associated with smoking and 70% greater (p=O.06) for alcohol consumption than those who were wild type. The XRCC3 Thr24l-Met substitution also showed a suggestive association with breast cancer risk.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA424044
Entities
People
- Roy E Shore
Organizations
- New York University